Ouch, this one really hurts. The Cubs set an MLB record for wins that still stands today (116-36) and face the crosstown rival, Chicago White Sox in the World Series. Ed Ruelbach pitches a one-hitter in game 2, but the White Sox won this series 4 games to 2.
October 9, 1906
Game 1, World Series
White Sox pitcher Nick Altrock outduels 3 Finger Brown as White Sox defeat Cubs 2-1.
October 10, 1906
Game 2, World Series
Ed Reulbach pitches a one-hitter as Cubs beat White Sox 7-1. The next 1-hitter in the World Series is in 1945 when Claude Passeau does it for Cubs against the Tigers.
October 11, 1906
Game 3, World Series
Ed Walsh pitches a 2-hitter as White Sox defeat Cubs 3-0 at West Side Grounds. White Sox take a 2 games to 1 lead in the 1906 World Series
October 12, 1906
Game 4, World Series
Another great pitching matchup as 3 Finger Brown pitches a 2-hitter against the White Sox and defeat Game 1 winner, Nick Altrock and the White Sox 1-0 at West Side Grounds.
October 13, 1906
Game 5, World Series
At West Side Grounds, the White Sox take a 3 games to 2 lead in the 1906 World Series with an 8-6 win over the Cubs.
October 14, 1906
Game 6, World Series
After Cubs win 116 games in regular season, they can't finish the deal as the White Sox defeat the Cubs 7-1 to win the WS 4 games to 2.